Alcon Science | United States

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Frequently Asked Questions (FAQ)

 

for Health Care Professionals

PLACEHOLDER SEARCH

Surgical

 

Active Sentry Handpiece

    The peel pack pouch is considered wrapped for sterilization purposes.

    Clareon (SY60WF)

      AcrySof® is made of PEA & PEMA with an Equilibrium Water Content (EWC) of 0.4%. Clareon™ is made of PEA and HEMA with an EWC of 1.5%. The precision edge design exists on both AcrySof and Clareon products; however, Clareon utilizes an advanced edge design process that consistently delivers smooth edge profile over the entire surface. Alcon recommends speaking with your surgeon for his or her recommendation of the most appropriate intraocular lens for your particular needs.

      As noted in the CLAREON® Product Information document, “Accurate biometry is essential for successful visual outcomes. Preoperative calculation of required lens power for the Clareon™ IOL should be determined by the surgeon’s experience and preference. A reference SRK/T A-Constant value for optical biometry equipment such as IOLMasterǂ or LenStarǂ as well as contact ultrasound biometry is listed on the outer label. The reference optical A-Constant anticipates the use of both corneal power and axial length values from optical biometry equipment with standard settings for a typical patient population and a spectacle far point at 6 meters. In general, A-Constants must be “personalized” to compensate for such things as differences in instrumentation, surgical techniques, and IOL power calculation that may exist between clinical practices.”

       

      The recommended starting points for CLAREON® SY60WF:
      The Optical SRK/T value is 119.1. 
      The Optical ACD value is 5.584 
      The Optical Surgeon Factor value is 1.824 
      The U/S SRK/T value is 118.8 
      The U/S Surgeon Factor value is 1.73 
      The U/S ACD value is 5.55

      CLAREON® intraocular lenses are not manufactured with graphene, graphene oxide or nanoparticles.

      CLAREON® intraocular lens models SY60WF and CC60WF were launched in the United States in early 2022, and are FDA approved.

      ACRYSOF® and CLAREON® intraocular lenses do not contain and are not coated with heparin.

      Clareon Vivity CCWET0

        Both the CLAREON VIVITY® IOL models CNWET0 & CNWET5 include a blue-light filtering chromophore designed to mimic the adult crystalline lens to reduce blue light transmission. As stated in the Directions for Use (DFU), the chromophore filters the light in a manner that approximates the human crystalline lens in the 400-475nm light wavelength range. Alcon suggests continuing to work with your surgeon and confirming the light wavelength(s) used in the light box treatment.

        Clareon Vivity CNWET0

          The interaction of Vivity intraocular lenses with progressive spectacle lenses has not been studied by Alcon. While there are no established contraindications for the two lenses, interactions of the visual system with optical systems are complex and multifactorial and best addressed through ongoing communication with an eye care provider.

          Hydrus Microstent

            Alcon does not have information or documentation regarding CT scan in the presence of the HYDRUS® Microstent; however, we would not expect safety issues with the product and x-rays. If imaging a feature in the vicinity of the implant (e.g., in the quadrant of the Schlemm’s canal where the stent is implanted), there may be a distortion of the image in and around the immediate surrounding of the implant.

            Alcon has not conducted studies for use of CPAP facemasks in conjunction with the HYDRUS® Microstent. The Hydrus is rated to 3Tesla and would not be expected to be affected by magnets in the ResMed CPAP facemask. Alcon would recommend speaking with the manufacturer of the sleep equipment and your physician for any additional information.

            VIVITY UVA & BLF IOL

              The interaction of Vivity intraocular lenses with progressive spectacle lenses has not been studied by Alcon. While there are no established contraindications for the two lenses, interactions of the visual system with optical systems are complex and multifactorial and best addressed through ongoing communication with an eye care provider.

              Pharmaceutical

               

              ICaps L&Z

                Ingredients: Vitamin A (100% as Beta-carotene), Vitamin C (ascorbic acid), Vitamin E (as d-alpha-tocopheryl acetate), Riboavin (Vitamin B2), Calcium (dicalcium phosphate), Zinc (as zinc oxide), Selenium (as selenium amino acid chelate), Copper (as copper citrate), Manganese (as manganese amino acid chelate).

                 

                Other Ingredients: Microcrystalline Cellulose, Hypromellose, Hydroxypropyl Methylcellulose, Vegetable Stearic Acid, Vegetable Magnesium Stearate, Silicon Dioxide, Polydextrose, Titanium dioxide, Maltodextrin, Talc, Medium chain triglycerides, Carnauba Wax.

                 

                Contains: Fish (cod, pollack, haddock, hake, cusk, redfish, sole, flounder).

                SYSTANE® ICAPS® Lutein & Zeaxanthin tablets do have ingredient(s) derived from fish.

                ICaps MV

                  The suggested adult intake is to take the SYSTANE® ICAPS® Multivitamin with two separate meals (two tablets twice per day with a meal). This is because the absorption systems can become oversaturated if all vitamins are taken at one time. In addition, water soluble components in the tablets will be excreted rapidly. In order to keep more sustained levels of the vitamin components over time, it may be more beneficial to take two separate doses.

                   

                  Alcon suggests speaking with your eye care professional for the most appropriate ocular multivitamin and dosage for your particular needs.

                  Systane

                    Systane® Lubricant Eye Drops Original Long-Lasting is not made with gluten; however, Alcon does not test for the presence or absence of gluten. As Alcon obtains raw materials from many different suppliers, Alcon is unable to state specifically that Systane Original would not cause a reaction for a given consumer/patient, including those with an allergy to gluten. Alcon recommends speaking with your eye care professional for their determination of which ocular lubricant would be best suited for your particular needs.

                    SYSTANE® Long-Lasting Lubricant Eye Drops are not made with ingredients derived from corn or wheat. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® Long-Lasting would not cause a reaction for a given patient, including those with an allergy to corn or wheat. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                    According to the SYSTANE® Lubricant Eye Drops Safety Data Sheet, for liquid disposal “Smaller quantities can be disposed of with household waste.”

                     

                    The bottle made of low-density polyethylene (#4) with a polypropylene (#5) tip and cap, and is recyclable in accordance with state and local collection regulations. Alcon recommends checking with your municipal recycling center for which materials are accepted for recycling in your region/area.

                    Systane Complete

                      SYSTANE® COMPLETE is not made with nickel. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that Systane® Complete would not cause a reaction for a given patient, including those with an allergy to nickel. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                      Systane® Complete is not indicated to be used with contact lenses. Alcon recommends speaking with your eye care professional regarding the most appropriate rewetting or lubricating eye drop for you depending on your medical history and the type of contact lenses you wear.

                      There are no contraindications for use of SYSTANE® COMPLETE by patients implanted with intraocular lenses. Please consult with your eye care professional who should answer your specific questions related to options for your individual care and determine the most appropriate ocular lubricant for your particular needs.

                      Systane Complete is recommended for use after the product has been shaken because shaking allows for a uniform delivery of the lipid-based product.

                       

                      If the product is inadvertently not shaken however, it will have a minimal impact on the performance due to the stability of the emulsion.

                      Systane Complete MDPF

                        White to off-white; Appearance is uniform emulsion.

                        SYSTANE® COMPLETE Preservative-Free does not contain steroids. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® COMPLETE Preservative-Free would not cause a reaction for a given patient, including those with an allergy to steroids. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                        OFF Label

                         

                        The labeling for Systane indicates the product should be stored at room temperature. The United States Pharmacopeia (USP) defines room temperature as 15°c - 30°c (59°F - 86°F). Storage of the sealed product within this temperature range ensures the product will remain stable throughout the shelf life indicated on the label. We do not recommend storage of the product outside of labeled conditions.

                        If stored and used according to label directions, Systane® Complete Preservative-Free Multidose should be discarded ninety (90) days after opening or at the expiration date on the package, whichever comes first.

                        SYSTANE® HYDRATION PF Eye Drops provide long-lasting hydration and restore moisture to dry eyes with HydroBoost Technology. HydroBoost Technology (HP-Guar + Sodium Hyaluronate) gives an extra moisturizing boost of hydration. SYSTANE® HYDRATION PF Eye Drops are indicated for use with aqueous dry eye.
                        SYSTANE® COMPLETE PF provides 8 hours of clinically proven relief for all major types of dry eye (aqueous deficient, evaporative/lipid deficient, and mixed). Its preservative-free formula is ideal for sensitive eyes.

                        For Systane® Complete PF Lubricant Eye Drops, the PureFlow Multi-Dose Preservative-Free technology prevents backflow and allows for sterile air return. Squeezing the bottle creates pressure and collapses a spring to allow the product to flow. Release of that pressure closes the valve and prevents backflow. The patented technology in the bottle does not let contamination back into the bottle.

                        DIRECTIONS:
                        Shake the bottle well before first opening.
                        Hold the bottle just below the cap and twist the cap to open.
                        BEFORE FIRST USE, hold the bottle at an approximate 90-degree angle and dispense one drop of product to discard. Shake the bottle downward to remove residual product (see picture).

                         

                        SYSTANE® COMPLETE Lubricant Eye Drops may be used as needed throughout the day to relieve the symptoms of dry eye. May also be used to relieve dry eye symptoms associated with contact lens usage by instilling drops prior to inserting contact lenses and after the removal of contact lenses.
                        Shake well before using.
                        Instill 1 or 2 drops in the affected eye(s) as needed and blink.
                        After use, before closing the cap on the bottle, shake the bottle downward to remove residual product that may be left on the tip (see picture).

                         

                        Close the bottle.

                         

                        Please visit https://systane.myalcon.com/products/systane-complete-preservative-free/ for more information.

                        The propylene glycol used in SYSTANE® COMPLETE Preservative-Free is manufactured by a synthetic process.

                        The formulation of SYSTANE® COMPLETE Preservative Free drops does not contain ingredients known to be habit forming. All of the components in this product are pharmacologically inert compounds or generally classified as non-toxic and non-irritating. Per the product label, SYSTANE® COMPLETE Preservative Free drops may be used as needed.

                        SYSTANE® COMPLETE Preservative-Free Multidose does not contain gelatin or collagen. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® COMPLETE Preservative-Free Multidose would not cause a reaction for a given patient, including those with an allergy to gelatin or collagen. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                        SYSTANE® COMPLETE Multi-dose Preservative-Free is not made with nickel. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that Systane® Complete Multi-dose Preservative-Free would not cause a reaction for a given patient, including those with an allergy to nickel. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                        Systane® Complete Preservative-Free multi-dose is not indicated to be used with contact lenses.

                        Alcon recommends speaking with your eye care professional regarding the most appropriate rewetting or lubricating eye drop for you depending on your medical history and the type of contact lenses you wear.

                        The first drop is to be dispensed and discarded before first using the product after opening only. This allows for proper flow of the product after opening.

                        Systane® Complete is recommended for use after the product has been shaken because shaking allows for a uniform delivery of the lipid-based product.

                         

                        If the product is inadvertently not shaken however, it will have a minimal impact on the performance due to the stability of the emulsion.

                        Systane Contacts

                          SYSTANE® CONTACTS Rewetting Eye Drops do not contain steroids.

                          Systane Ultra UD

                            The labeling for Systane® Ultra Unit Dose indicates the product should be stored at room temperature. The United States Pharmacopeia (USP) defines room temperature as 15°C – 30°C (59°F - 86°F). Storage of the sealed product within this temperature range ensures the product will remain stable throughout the shelf life indicated on the label. Alcon does not recommend storage of the product outside of labeled conditions.

                            Systane UD

                              SYSTANE® Preservative Free Lubricant Eye Drops are not made with ingredients derived from corn or wheat. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® Preservative-Free would not cause a reaction for a given patient, including those with an allergy to corn or wheat. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                              Systane Ultra

                                SYSTANE® ULTRA lubricant eye drops is supplied in a Low Density Polyethylene (LDPE) plastic bottle and dispensing tip, with a polypropylene (PP) cap.

                                Systane Ultra MDPF

                                  If stored and used according to label directions, Systane® Ultra Multi-dose Preservative-Free should be discarded 90 days after opening or at the expiration date on the package, whichever comes first.

                                  For SYSTANE® ULTRA PF Lubricant Eye Drops, the PureFlow Multi-Dose Preservative-Free technology prevents backflow and allows for sterile air return. Squeezing the bottle creates pressure and collapses a spring to allow the product to flow. Release of that pressure closes the valve and prevents backflow. The patented technology in the bottle does not let contamination back into the bottle.

                                  SYSTANE® ULTRA Preservative-Free does not contain oils.

                                  SYSTANE® ULTRA Preservative-Free Multidose is not indicated to be used with contact lenses. Contact lens wearers can use the product before inserting or after taking out their contact lenses. Alcon recommends speaking with your eye care professional regarding the most appropriate rewetting or lubricating eye drop for you depending on your medical history and type of contact lenses you wear.

                                  Systane Gel Drops

                                    The formulation is the same for GenTeal® Tears Gel Drops and Systane® Gel Drops.

                                    Systane Gel Overnight Therapy

                                      SYSTANE® Lubricant Eye Gel Overnight does not contain elemental sulfur or compounds with sulfur ions. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® GEL Overnight would not cause a reaction for a given patient, including those with an allergy to sulfur. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                      SYSTANE® Lubricant Eye Gel Overnight does not contain elemental sulfur or compounds with sulfur ions. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® GEL Overnight would not cause a reaction for a given patient, including those with an allergy to sulfur. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                      Systane Hydration MD PF

                                        If stored and used according to label directions, Systane Hydration Multidose Preservative-Free should be discarded three (3) months after opening or at the expiration date on the package, whichever comes first.

                                        The first drop is to be dispensed and discarded before first using the product after opening only. This allows for proper flow of the product after opening.

                                        Gelatin and collagen are not an ingredient in the formulation of SYSTANE® HYDRATION Preservative-Free drops. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® HYDRATION Preservative-Free would not cause a reaction for a given patient, including those with an allergy to gelatin or collagen. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                        SYSTANE® HYDRATION Preservative-Free Lubricant Eye Drops does not contain ingredients derived from animals.

                                        Systane® Hydration Preservative-Free multi-dose is not indicated to be used with contact lenses.
                                        Alcon recommends speaking with your eye care professional regarding the most appropriate rewetting or lubricating eye drop for you depending on your medical history and the type of contact lenses you wear.

                                        Systane Hydration PF

                                          Hydroboost Technology is a unique combination that helps retain the lubricants, for lasting dry eye symptom relief without preservatives.

                                          SYSTANE® HYDRATION PF Eye Drops provide long-lasting hydration and restore moisture to dry eyes with HydroBoost Technology. HydroBoost Technology (HP-Guar + Sodium Hyaluronate) gives an extra moisturizing boost of hydration. SYSTANE® HYDRATION PF Eye Drops is indicated for use with aqueous dry eye.

                                           

                                          Active Ingredients

                                          Purpose

                                          Polyethylene Glycol 400 0.4%

                                          Lubricant

                                          Propylene Glycol 0.3%

                                          Lubricant

                                           

                                          Inactive Ingredients: Aminomethylpropanol, boric acid, hydroxypropyl guar, potassium chloride, purified water, sodium borate, sodium chloride, sodium hyaluronate, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.

                                           

                                          SYSTANE® ULTRA PF Eye Drops are clinically proven to deliver extended protection and high-performance dry eye symptom relief that lasts, and helps your eyes feel lubricated and refreshed. SYSTANE® ULTRA PF Eye Drops is indicated for use with aqueous dry eye.

                                           

                                          Active Ingredients

                                          Purpose

                                          Polyethylene Glycol 400 0.4%

                                          Lubricant

                                          Propylene Glycol 0.3%

                                          Lubricant

                                           

                                          Inactive Ingredients: Aminomethylpropanol, boric acid, hydroxypropyl guar, potassium chloride, purified water, sodium chloride, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.

                                          SYSTANE® HYDRATION PF Lubricant Eye Drops does not contain any material derived from grain (including corn), dairy, egg, soy, nuts, or coconut. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® HYDRATION PF would not cause a reaction for a given patient, including those with an allergy to grain, dairy, egg, soy, nuts, or coconut. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                          Systane PM

                                            SYSTANE® OINTMENT Nighttime Relief in Canada is the same formulation as SYSTANE® NIGHTTIME Severe Dry Eye Relief Lubricant Eye Ointment in the United States.

                                            Excess Systane® Nighttime Lubricant Eye Ointment on your eyelids can be removed with a clean, warm, wet washcloth, or by your usual skin-cleansing process.

                                            SYSTANE® NIGHTTIME OINTMENT does not contain a preservative, and is preservative-free.

                                            Zaditor

                                              Zaditor® is not formulated with chemicals originating or derived from animal sources. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that Zaditor® would not cause a reaction for a given patient, including those with an allergy to animal-derived ingredients. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                              Systane® Zaditor® antihistamine eye drops are not formulated with ingredients derived from tree nuts, including coconut. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that Systane® Zaditor® would not cause a reaction for a given patient, including those with an allergy to coconut or its derivatives. Alcon recommends the patient consult their allergist and eye care professional to determine the best options for their particular needs.

                                              ZADITOR® is not made with corn or corn derivatives. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that ZADITOR® would not cause a reaction for a given patient, including those with an allergy to corn or its derivatives. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                                              There are no ingredients in SYSTANE® ZADITOR® which are known to affect heart rate. There are no precautions or contraindications in the label for the product regarding effects on heart rate.

                                               

                                              Alcon recommends speaking with your eye care professional for the most appropriate products for your particular needs.

                                              Alcaine

                                                The raw materials used to manufacture Alcaine® do not contain or contact animal tissues or derivatives. Despite the lack of these ingredients, Alcon is unable to state specifically that Alcaine® would not cause a reaction for a given patient, including those with an allergy to animal-derived ingredients. Alcon recommends working with the patient’s allergist for guidance.

                                                Cyclogyl

                                                  The raw materials in CYCLOGYL® are not of animal origin. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that CYCLOGYL® would not cause a reaction for a given patient, including those with an allergy to animal derivatives or alpha-gal. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                  Eysuvis

                                                    EYSUVIS® is not made with carrageenan or its derivatives. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that EYSUVIS® would not cause a reaction for a given patient, including those with an allergy to carrageenan or its derivatives. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                                                    EYSUVIS® does not contain ingredients derived from animals.

                                                    Care should be taken to store EYSUVIS® upright. Alcon internal data indicate inverted (upside down) bottles may experience stability issues, so an inverted bottle should be avoided.

                                                    EYSUVIS® does not have any sulfur-based ingredients.


                                                    [If allergy related, include the following text]:

                                                     

                                                    Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that EYSUVIS® would not cause a reaction for a given patient, including those with an allergy to sulfur. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                    EYSUVIS® does not contain latex or dry natural rubber and is considered latex-free.

                                                    GenTeal Tears Gel Drops

                                                      If stored and used according to label directions, GenTeal® Tears Gel Drops should be discarded 28 days after opening or at the expiration date on the package, whichever comes first.

                                                      GENTEAL® TEARS Gel Drops does not contain steroids.

                                                      GenTeal Tears Moderate

                                                        If stored and used according to label directions, GENTEAL® TEARS MODERATE should be discarded twelve (12) weeks after first opening or at the expiration date on the package, whichever comes first.

                                                        GENTEAL® TEARS MODERATE does not contain lactose. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that GENTEAL® TEARS MODERATE would not cause a reaction for a given patient, including those with an allergy to lactose. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                                                        GenTeal Tears Night-Time Ointment

                                                          GenTeal® Tears Severe Eye Ointment contains mineral oil and white petrolatum, and is gentle on your eyes throughout the night to help reduce dryness and relieves irritation after exposure to wind or sun. The product is best for use at night, applying a small amount of ointment to the inside of the eyelid.

                                                           

                                                          GenTeal® Tears Lubricant Eye Gel contains hypromellose 0.3%, to relieve dryness of the eye and temporarily relieve discomfort due to minor irritations of the eye or to exposure to wind or sun. GenTeal® Tears Lubricant Eye Gel may also be used as a protectant against further irritation.

                                                           

                                                          As each individual’s needs and preferences will vary, Alcon recommends speaking with your eye care professional for their recommendation of the most appropriate ocular lubricant for you.

                                                          All of the components of GENTEAL® TEARS NIGHTTIME OINTMENT are pharmacologically inert compounds or generally classified as non-toxic and non-irritating. Please consult with your eye care professional for his or her determination of the most appropriate ocular lubricant for your particular needs.

                                                          The QR code is used to help identify which machine was used for manufacturing, as part of our internal product tracking.

                                                          ICaps AREDS 2 Tablet

                                                            SYSTANE® ICAPS® AREDS2 coated tablets are not made with iodine. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that the product would not cause a reaction for a given patient, including those with an allergy to iodine. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                            ICAPS AREDS 2

                                                              There is a difference in the source of vitamin E from natural (d-alpha) used in the coated tablet compared to synthetic (dl-alpha) used in the softgel. The coated tablet formulation has 134 mg x 2 tablets = 268 mg of vitamin E in its natural form, whereas the softgel formula has 90 mg x 2 softgels daily = 180 mg of vitamin E in its synthetic form. The source of vitamin E changes the potency calculation in milligrams (mg) but maintains the same dosage in international units (IUs), 400 IUs in both formulas.

                                                              As noted on the carton label, “Softgels should be consumed whole. Do not consume damaged softgels.” Alcon recommends speaking with your eye care professional for the most appropriate eye vitamin and mineral supplement for your particular needs.

                                                              SYSTANE® ICAPS® AREDS2 Softgels are free of vitamin A for individuals who should avoid beta carotene. Beta carotene, the conventional source of vitamin A, is contraindicated for smokers, an important risk category for Age-Related Macular Degeneration (AMD).

                                                              Inveltys

                                                                INVELTYS® is not made with carrageenan or its derivatives. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that INVELTYS® would not cause a reaction for a given patient, including those with an allergy to carrageenan or its derivatives. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                                                                INVELTYS® (loteprednol etabonate ophthalmic suspension) 1% is stable when stored upright at 15°C to 25°C (59°F to 77°F) with the pink cap tightly closed. INVELTYS should not be frozen.1 After opening, INVELTYS can be used until the expiration date on the bottle.

                                                                 

                                                                Reference(s) 
                                                                1. INVELTYS® Package Insert. Watertown, MA: Kala Pharmaceuticals, Inc.; 2020.

                                                                Care should be taken to store INVELTYS® upright. Alcon internal data indicate inverted (upside down) bottles may experience stability issues, so an inverted bottle should be avoided.

                                                                INVELTYS® does not contain latex or dry natural rubber and is considered latex-free.

                                                                INVELTYS® is manufactured in the U.S.A.

                                                                INVELTYS® does not contain ingredients derived from animals.

                                                                Isopto Tears

                                                                  The viscosity of Isopto Tears is considered proprietary and is not published.

                                                                   

                                                                  Alcon does not promote or recommend any alterations of any kind to our products. This would alter the pH, preservative system, and other aspects of the product. Once an Alcon product has been altered, Alcon cannot guarantee the efficacy or safety of the product. Alcon can only support the use of its products as outlined in the product labeling documents. Any use of the product outside its approved indication is at the discretion and risk of the healthcare professional. Alcon does not recommend the use of any of its products for other than approved indications. Physicians should carefully assess all relevant efficacy and safety data of Isopto Tears for each individual patient’s condition or treatment before making any decision to use or prescribe the product.

                                                                  Naphcon A

                                                                    The raw materials in NAPHCON A® are not of animal origin. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that NAPHCON A would not cause a reaction for a given patient, including those with an allergy to animal derivatives or alpha-gal. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                                    The product composition/ingredients of Naphcon A® eye drops do not contain corn and wheat and the product is not made with corn or wheat.
                                                                    However, Alcon does not test for the presence or absence of corn or wheat. Alcon is unable to state specifically that Naphcon A® eye drops would not cause a reaction for a given patient, including those with an allergy to corn and wheat.

                                                                    Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.”

                                                                    No Pharma Product

                                                                      SYSTANE® brand ocular lubricants do not contain steroids.

                                                                      The ingredients of Alcon over-the-counter (OTC) products do not contain PFAS.

                                                                      SYSTANE® brand lubricant eye drops are not formulated with ingredients derived from animals. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SYSTANE® brand lubricant eye drops would not cause a reaction for a given patient, including those with an allergy to animal-derived ingredients. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                                      Pataday Extra Strength

                                                                        When stored and used according to label directions, Pataday® (olapatadine hydrochloride ophthalmic solution 0.7%) should be discarded four (4) weeks after opening or at the expiration date on the package, whichever comes first.

                                                                        Pataday® products do not contain any raw materials that may contain soy. Lanolin is not an ingredient in the formulation of Pataday® products. However, raw material suppliers for Pataday® do not all state with certainty that there is no lanolin in the raw materials. Because of these qualifications, Alcon cannot certify that there are no traces of lanolin in Pataday®. Alcon is unable to state specifically that Pataday® products would not cause a reaction for a given patient, including those with an allergy to soy or lanolin. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                                        Pataday® Extra-Strength is indicated for the temporary relief of itchy eyes due to pollen, ragweed, grass, animal hair and dander. There are no known contraindications or warnings for use of Pataday® Extra-Strength in patients with glaucoma disease.

                                                                        [ATTN MPI: reports of overdose must be reported to Safety]
                                                                        No reports of overdose were received during the Pazeo™ clinical studies. Alcon is unable to provide medical advice; however, due to the characteristics of this preparation, no toxic effects are to be expected with an accidental ocular overdose of two drops instead of one for PATADAY® Once Daily Extra Strength 0.7%. Alcon does not have data on the long-term effects of overdose with PATADAY® Once Daily Extra Strength.
                                                                        Alcon does not recommend the use of any of its products for other than approved indications. Physicians should carefully assess all relevant efficacy and safety data of PATADAY® Once Daily Extra Strength for each individual patient’s condition or treatment before making any decision to use or prescribe the product.

                                                                        Coconut is not an ingredient in the formulation of PATADAY® Once Daily Extra Strength. However, raw material suppliers for PATADAY® Once Daily Extra Strength do not all state with certainty that there is no coconut in the raw materials. A coconut filter is not used during manufacturing. Because of these qualifications, Alcon cannot certify that there are no traces of coconut in PATADAY® Once Daily Extra Strength. Alcon recommends that the patient and healthcare provider work together to determine the best options for each individual patient.

                                                                        PATADAY® Once Daily, PATADAY® Twice Daily, and PATADAY® Once Daily Extra Strength do not contain steroids. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that PATADAY® Once Daily, PATADAY® Twice Daily, and PATADAY® Once Daily Extra Strength would not cause a reaction for a given patient, including those with an allergy to steroids. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                                        PATADAY® (olopatadine hydrochloride ophthalmic solution 0.7%) Once Daily Relief Extra Strength does not contain any raw material that may contain tree nuts. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that Pataday® Once Daily Extra Strength would not cause a reaction for a given patient, including those with an allergy to tree nuts. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                                        Pataday Once Daily

                                                                          Pataday® Once Daily is indicated for the temporary relief of itchy eyes due to pollen, ragweed, grass, animal hair and dander. There are no known contraindications or warnings for use of Pataday® Once Daily in patients with glaucoma disease.

                                                                          Pataday® (olapatadine hydrochloride) ophthalmic solution antihistamine is preserved with benzalkonium chloride 0.01%.

                                                                          [ATTN MPI: reports of overdose must be reported to Safety]
                                                                          Alcon is unable to provide medical advice; however, due to the characteristics of this preparation, no toxic effects are to be expected with an accidental ocular overdose of two drops instead of one for PATADAY® Once Daily 0.2%. Alcon does not have data on the long-term effects of overdose with PATADAY® Once Daily.
                                                                          Alcon does not recommend the use of any of its products for other than approved indications. Physicians should carefully assess all relevant efficacy and safety data of PATADAY® Once Daily for each individual patient’s condition or treatment before making any decision to use or prescribe the product.

                                                                          Hydrochloric acid may be added to PATADAY® ONCE DAILY to adjust the pH of the final product.

                                                                          Pataday Twice Daily

                                                                            Pataday® Twice Daily is indicated for the temporary relief of itchy eyes due to pollen, ragweed, grass, animal hair and dander. There are no known contraindications or warnings for use of Pataday® Twice Daily in patients with glaucoma disease.

                                                                            Pataday® (olapatadine hydrochloride) ophthalmic solution antihistamine is preserved with benzalkonium chloride 0.01%.

                                                                            PATADAY® Twice Daily (olopatadine 0.1%) is an antihistamine primarily used to provide eye allergy itch relief. PATADAY® Twice Daily is not an antibiotic and does not contain doxycycline. Among 492 subjects treated with olopatadine 0.1% in the FDA clinical studies, there was one reported incident of ear pain (0.2%).
                                                                            Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that PATADAY® Twice Daily would not cause a reaction for a given patient, including those with an allergy to doxycycline. Your allergist and eye care professional may wish to work together to determine the most appropriate option for your particular needs.

                                                                            Rhopressa

                                                                              Per the ROCKLATAN® and RHOPRESSA® Prescribing Information, “Storage: Protect from light. Until opened, store at 2°C to 8°C (36°F to 46°F). After opening, the product may be kept at 2°C to 25°C (36°F to 77°F) for up to 6 weeks. If after opening the product is kept refrigerated at 2°C to 8°C (36°F to 46°F), then the product can be used until the expiration date stamped on the bottle. During shipment, the bottle may be maintained at temperatures up to 40°C (104°F) for a period not exceeding 14 days.”
                                                                              Alcon cannot assure the safety and effectiveness of products stored outside of the labeled conditions; however, whether opened or unopened ROCKLATAN® and RHOPRESSA® may be kept at room temperature [2°C to 25°C (36°F to 77°F)] for up to 6 weeks. If the product is refrigerated [2°C to 8°C (36°F to 46°F)] within that time frame, then it can be used until the expiration date stamped on the bottle. 
                                                                              If ROCKLATAN® or RHOPRESSA® was not at room temperature [2°C to 25°C (36°F to 77°F)] for more than 6 weeks, it can be placed back under refrigeration [2°C to 8°C (36°F to 46°F)] and used until the expiration date stamped on the bottle. If there is visible physical damage, including wetness/dampness or warpage, the product may have been compromised.

                                                                              Per the ROCKLATAN® and RHOPRESSA® Prescribing Information, “Storage: Protect from light. Until opened, store at 2°C to 8°C (36°F to 46°F). After opening, the product may be kept at 2°C to 25°C (36°F to 77°F) for up to 6 weeks. If after opening the product is kept refrigerated at 2°C to 8°C (36°F to 46°F), then the product can be used until the expiration date stamped on the bottle. During shipment, the bottle may be maintained at temperatures up to 40°C (104°F) for a period not exceeding 14 days.”
                                                                              Alcon cannot assure the safety and effectiveness of products stored outside of the labeled conditions; however, stability testing was conducted for ROCKLATAN® and RHOPRESSA® down to a temperature of -20°C and product quality is not impacted by temperature below 36°F. Product should be fully thawed before using. If there is visible physical damage, including wetness/dampness or warpage, the product may have been compromised.

                                                                              Rocklatan

                                                                                Per the ROCKLATAN® and RHOPRESSA® Prescribing Information, “Storage: Protect from light. Until opened, store at 2°C to 8°C (36°F to 46°F). After opening, the product may be kept at 2°C to 25°C (36°F to 77°F) for up to 6 weeks. If after opening the product is kept refrigerated at 2°C to 8°C (36°F to 46°F), then the product can be used until the expiration date stamped on the bottle. During shipment, the bottle may be maintained at temperatures up to 40°C (104°F) for a period not exceeding 14 days.”
                                                                                Alcon cannot assure the safety and effectiveness of products stored outside of the labeled conditions; however, whether opened or unopened ROCKLATAN® and RHOPRESSA® may be kept at room temperature [2°C to 25°C (36°F to 77°F)] for up to 6 weeks. If the product is refrigerated [2°C to 8°C (36°F to 46°F)] within that time frame, then it can be used until the expiration date stamped on the bottle. 
                                                                                If ROCKLATAN® or RHOPRESSA® was not at room temperature [2°C to 25°C (36°F to 77°F)] for more than 6 weeks, it can be placed back under refrigeration [2°C to 8°C (36°F to 46°F)] and used until the expiration date stamped on the bottle. If there is visible physical damage, including wetness/dampness or warpage, the product may have been compromised.

                                                                                Per the ROCKLATAN® and RHOPRESSA® Prescribing Information, “Storage: Protect from light. Until opened, store at 2°C to 8°C (36°F to 46°F). After opening, the product may be kept at 2°C to 25°C (36°F to 77°F) for up to 6 weeks. If after opening the product is kept refrigerated at 2°C to 8°C (36°F to 46°F), then the product can be used until the expiration date stamped on the bottle. During shipment, the bottle may be maintained at temperatures up to 40°C (104°F) for a period not exceeding 14 days.” Alcon cannot assure the safety and effectiveness of products stored outside of the labeled conditions; however, stability testing was conducted for ROCKLATAN® and RHOPRESSA® down to a temperature of -20°C and product quality is not impacted by temperature below 36°F. Product should be fully thawed before using. If there is visible physical damage, including wetness/dampness or warpage, the product may have been compromised.

                                                                                Simbrinza

                                                                                  None of the excipients used in SIMBRINZA® are of animal origin. An internal review of all cumulative adverse event cases was conducted and there have been no known adverse events reported for Alpha-gal allergy. In addition, Alcon reviewed all events reported under the term “immune system disorders” and did not find any results indicative of Alpha-gal reaction.

                                                                                   

                                                                                  Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that SIMBRINZA® would not cause a reaction for a given patient, including those with an allergy to alpha-gal. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                                                  The bottle, nozzle, and cap of SIMBRINZA® are not formulated with latex; however, latex gloves may be used by operators during manufacturing operations. Therefore, the product cannot be indicated as latex free.

                                                                                  The difference in approved SIMBRINZA® dosing frequency is based on each region’s regulatory requirements and review of the clinical trial data. Per the U.S. SIMBRINZA® Prescribing Information, “Instill one drop in the affected eye(s) three times daily.” Specific questions pertaining to your medical condition and appropriate treatment should be directed to your health care provider.

                                                                                  Contact Lens

                                                                                   

                                                                                  Air Optix Aqua Colors

                                                                                    AIR OPTIX® COLORS are designed to work on both light and dark eyes, including brown eyes. The final result may vary based on the patient’s natural color and the lighting conditions.

                                                                                    AIR OPTIX® COLORS does not contain a preservative in the blister pack. Each lens is packaged in a foil-sealed plastic container containing isotonic phosphate buffered saline with 0.2% VP/DMAEMA Copolymer and is steam sterilized.

                                                                                    DAILIES® COLORS deliver color enhancement with an eye-defining ring. AIR OPTIX® COLORS are designed to enhance or transform dark or light eyes.
                                                                                    FRESHLOOK® COLORBLENDS® are opaque colors for dark or light eyes.

                                                                                    Air Optix HydraGlyde

                                                                                      Neither AIR OPTIX® plus HydraGlyde® soft contact lenses nor the package storage saline is manufactured with boric acid.

                                                                                      Alcon contact lens materials are not manufactured from ingredients derived from animals, and do not contain the ‘alpha-gal’ (galactose-alpha-1,3-galactose) molecule. Despite the lack of alpha-gal, Alcon is unable to state specifically that a contact lens product would not cause a reaction for a given patient. Alcon recommends working with the patient’s allergist for guidance.

                                                                                      The blister pack solution of AIR OPTIX® plus HydraGlyde® contact lenses is a phosphate buffered saline that contains 0.2% vinylpyrrolidone/Dimethylmethacrylate (VP/DMAEMA) and 0.04% polyoxyethylene-polyoxybutylene wetting agents.

                                                                                       

                                                                                      [Note: If additional information is needed]
                                                                                      The copolymer 845 is a moisturizing/cushioning agent, and HydraGlyde Moisture Matrix is used for longer lasting lens surface wettability.

                                                                                      Air Optix HG for Astigmatism

                                                                                        Neither AIR OPTIX® plus HydraGlyde® soft contact lenses nor the package storage saline is manufactured with boric acid.

                                                                                        Air Optix Night & Day Aqua

                                                                                          Smartshield® is the unique, permanent plasma surface technology of the AIR OPTIX® family of contact lenses. Smartshield® technology has been a part of AIR OPTIX® NIGHT & DAY® AQUA contact lenses since its introduction in March 2009.

                                                                                          One way to tell if the lens is right side out is to place the lens between your thumb and index finger and squeeze the edges together gently.

                                                                                          • If the edges come together, the lens is right side out.
                                                                                          • If the edges turn outward, the lens is wrong side out. Carefully reverse it with the fingers.

                                                                                           

                                                                                          Another way is to place the lens on the tip of the index finger and check its shape.

                                                                                          • If the edge appears bowl-shaped, it is right side out.
                                                                                          • If the edge has a lip or flares outward, it is wrong side out and must be reversed.

                                                                                           

                                                                                          A third way to tell if the lens is right side out is to look at the lens engravings at the edge of the lens.

                                                                                          • Place the lens on the tip of the index finger and hold it up against a light source.
                                                                                          • If the lens is right side out, the patient should be able to read "CIBA" at the edge of the lens.
                                                                                          • If the lens is inside out, the engravings will be reversed. Carefully turn the lens right side out with the fingers.

                                                                                          Clear Care Plus

                                                                                            An unused CLEAR CARE® lens case does not have an expiration date. For your convenience, a new fresh lens case is supplied with each solution purchase, regardless of size. For packages with more than 32 fl. oz. of CLEAR CARE Solution, an additional lens case is provided. Alcon recommends disposing of your old lens case with each new purchase of CLEAR CARE Cleaning & Disinfecting Solution.

                                                                                            Alcon now laser prints lot numbers on the lid of the CLEAR CARE® and CLEAR CARE® PLUS lens cases.

                                                                                            CLEAR CARE® PLUS is not formulated with ingredients derived from corn or sunflower. Despite the lack of these ingredients in the formulation, Alcon is unable to state specifically that CLEAR CARE PLUS would not cause a reaction for a given patient, including those with an allergy to corn or sunflower. Alcon recommends the patient’s allergist and eye care professional work together to determine the most appropriate option for the patient’s particular needs.

                                                                                            CLEAR CARE® PLUS Cleaning & Disinfecting Solution is supplied with a new lens case with each purchase. Always use the new lens case provided with each purchase of CLEAR CARE® PLUS. Both the original white lens case provided with CLEAR CARE® and the blue/white lens case provided with CLEAR CARE® PLUS with HydraGlyde® are similar in performance.

                                                                                            A fresh new lens case is supplied with each purchase of CLEAR CARE®. The lens case consists of a transparent cup and a connected unit of screw cap, lens holders (baskets) and the neutralizer catalyst disc attached at the bottom.

                                                                                            For ECPs only:
                                                                                            CLEAR CARE® is manufactured with a 23-month shelf life from the date of manufacture and is labeled with the corresponding expiration date. Alcon guarantees the safety and efficacy of CLEAR CARE until the labeled expiration date. Alcon does not recommend the use of expired product.

                                                                                             

                                                                                            For Consumers:
                                                                                            CLEAR CARE® is has an established shelf life from the date of manufacture and is labeled with the corresponding expiration date. Alcon guarantees the safety and efficacy of CLEAR CARE until the labeled expiration date. Alcon does not recommend the use of expired product.

                                                                                            Alcon now laser prints lot numbers on the lid of the CLEAR CARE® and CLEAR CARE® PLUS lens cases.

                                                                                            The red tip and cap for CLEAR CARE® are a reminder for the consumer that the unneutralized solution is not to be inserted directly into the eyes or directly to the contacts prior to insertion, in order to avoid burning and stinging.

                                                                                            The CLEAR CARE® PLUS Lens Case is not sold separately. The CLEAR CARE PLUS lens case (lens cup and platinum coated neutralizer disc) is specially designed for use only with CLEAR CARE and CLEAR CARE PLUS Cleaning & Disinfecting Solution and must always be used together. For your convenience, a fresh new lens case is supplied with each solution purchase, regardless of size. For packages with more than 32 fl. oz. of CLEAR CARE PLUS solution, an additional lens case is provided. Dispose of your old CLEAR CARE PLUS lens case with each new purchase of CLEAR CARE PLUS solution.

                                                                                            Dailies AquaComfort Plus

                                                                                              All acrylates in DAILIES® AQUACOMFORT PLUS® are polymerized during the manufacturing process; therefore, no acrylates are left in the final product. Despite this polymerization, Alcon is unable to state specifically that DAILIES AQUACOMFORT PLUS would not cause a reaction for a given patient, including those with an allergy to acrylates. The patient’s allergist and eye care professional may wish to work together to determine the most appropriate option for the patient’s particular needs.

                                                                                              Dailies Colors

                                                                                                Neither DAILIES® COLORS soft contact lenses nor the package storage saline is manufactured with boric acid.

                                                                                                Dailies Total1 for Astigmatism

                                                                                                  DAILIES TOTAL1® for Astigmatism reduce high energy visible light (HEVL) radiation reaching the back of the eye by about 33% in the range from 380 nm to 450 nm.
                                                                                                  High energy visible light filtering provided by delefilcon A soft contact lenses with light absorbing chromophores is additive to the natural crystalline lens. There is no demonstrated clinical benefit to a 33% reduction in visible light at wavelengths below 450 nm. The Eye Care Professional should be consulted for more information.
                                                                                                  Please refer to the DAILIES TOTAL1 for Astigmatism package insert for full details.

                                                                                                  Dailies Total1 Multifocal

                                                                                                    For the DAILIES® TOTAL1 Multifocal (delefilcon A) One-Day Contact Lens, the contact lens material or the packaging of the blister pack (plastic container and foil lidding) is not made with natural rubber latex.

                                                                                                    DAILIES TOTAL1® Multifocal contact lenses are manufactured in Germany.

                                                                                                    Alcon multifocal contacts are aspheric with near power in the center of the lens, gradually transitioning to the intermediate and distance powers as it moves forward. The decision to be fit with multifocal lenses or a monovision correction should be made in conjunction with your eye care professional only after carefully considering and discussing your needs.

                                                                                                    • When about to place the lens on the eye, make sure the lens sits up on the placement finger. The finger should be dry so surface tension does not cause the lens to adhere to the finger.
                                                                                                    • Check to see that the lens is right side out. A lens that is placed on the eye inside out may not feel comfortable or provide good vision.

                                                                                                     

                                                                                                    One way to do this is to perform the 'taco test' by placing the lens between your thumb and index finger and squeeze the edges together gently.

                                                                                                    • If the edges come together, the lens is right side out.
                                                                                                    • If the edges turn outward, the lens is wrong side out. Carefully reverse it with your fingers.

                                                                                                     

                                                                                                    Another way is to place the lens on the tip of your index finger and check its shape.

                                                                                                    • If the edge appears bowl-shaped, it is right side out.
                                                                                                    • If the edge has a lip or flares outward, it is wrong side out and must be reversed.
                                                                                                    • Place the lens directly onto the cornea (placing it on the lower sclera can lead to the lens folding after a blink). While continuing to hold both lids in place, the patient should look down to seat the lens. The lids may then be released.

                                                                                                    Air Optix Aqua

                                                                                                      Alcon will be discontinuing AIR OPTIX® AQUA, AIR OPTIX® for Astigmatism, and AIR OPTIX® AQUA Multifocal revenue contact lenses. We will continue to fulfill orders, while supplies last, until the discontinuance date of 09/30/2021.

                                                                                                       

                                                                                                      Consumers may consider asking their eye care professional if the AIR OPTIX® plus HydraGlyde® contact lenses would be suitable for their particular needs. AIR OPTIX® plus HydraGlyde® contact lenses bring together two advanced technologies: SmartShield® Technology for deposit protection and HydraGlyde® Moisture Matrix for long lasting lens surface moisture.

                                                                                                      FreshLook ColorBlends

                                                                                                        FreshLook® ColorBlends® is an opaque print pattern designed to change eye color, whereas FreshLook® Dimensions™ is an enhancer designed to enhance natural eye color.

                                                                                                        As the lenses are different materials, base curves, and diameters, a refit would be required when switching from FRESHLOOK® COLORBLENDS® to AIR OPTIX® COLORS or DAILIES® COLORS.

                                                                                                        Unfortunately, Alcon no longer manufactures a colored contact lens in the same FRESHLOOK® material and dimensions; however, Alcon does manufacture AIR OPTIX® COLORS and DAILIES® COLORS contact lenses. Please consult with your Eye Care Professional so they can recommend the best lens for you and your lifestyle needs.

                                                                                                        iLux

                                                                                                          As noted in the iLux® User Manual, patients with aphakia are contraindicated for the procedure. Since the crystalline lens serves as an additional protective barrier for the retina against ultraviolet (UV) and infrared (IR) light, its absence can cause increased risk of UV and IR exposure to the retina and cause permanent damage.

                                                                                                          No CP Product

                                                                                                            To ensure the quality, safety and efficacy of medical devices and treatments, regulatory health authorities worldwide often require that new medical therapies are first evaluated in animal models as part of the approval process prior to human clinical trials. As we continue expanding the frontiers of sight-saving and vision-restoring products and services, Alcon embraces its responsibility to comply with these regulations. We are committed to upholding the highest standards of animal welfare and care whenever animals are involved in Alcon-initiated research studies. Treating animals with the best possible care is not only the right thing to do—it also produces better scientific outcomes through greater accuracy, reliability and relevance. When in vivo models are required, Alcon uses the absolute minimum number of laboratory animals necessary to provide scientifically meaningful results.
                                                                                                            Alcon meets or exceeds U.S. and international regulations including the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals. Alcon has maintained accreditation from the United States Department of Agriculture (USDA) and the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC), through which we hold the highest rating. We also follow the internationally accepted ethical principles known as the “3 Rs.” These are:

                                                                                                            • Replace tests with non-animal testing methods wherever possible and appropriate.
                                                                                                            • Reduce the number of animals used in each study.
                                                                                                            • Refine testing to use the least invasive methods feasible.

                                                                                                             

                                                                                                            Further, Alcon’s own addition – or “4th R” – to this global standard is:

                                                                                                            • Respect the inherent integrity of the animal and its contribution to our research.

                                                                                                            Alcon contact lenses have been shown to be safe and are used daily by millions of people in more than 140 countries. All of Alcon’s contact lenses meet our stringent internal safety standards and comply with the regulatory requirements of the U.S. Food and Drug Administration, European Chemicals Agency, or similar regulatory bodies in all of the markets in which we sell our products.
                                                                                                            Alcon continually monitors and evaluates emerging science and information about the materials we use so that we can keep earning the trust of the eye care professionals and consumers we serve. We are aware of media coverage of a recent report concerning contact lenses, which purports to measure total organic fluorine in certain contact lenses. Alcon questions the results of that report. For example, DAILIES TOTAL1® and TOTAL30® contact lenses do not contain organic fluorine in their formulation. Alcon is requesting a copy of the report to better understand how it reached its conclusions.
                                                                                                            Alcon remains committed to maintaining our legacy of manufacturing contact lenses to the highest quality and safety standards. In the meantime, consumers can confidently use all Alcon contact lenses.

                                                                                                            Alcon contact lenses do not contain bisphenol or phthalates.

                                                                                                            [NOTE TO MPI: Only provide the response applicable to the product requested]

                                                                                                             

                                                                                                            DAILIES TOTAL1® sphere is manufactured in the United States.

                                                                                                            DAILIES TOTAL1® multifocal is manufactured in Germany.

                                                                                                            DAILIES TOTAL1® toric is manufactured in Germany.

                                                                                                            TOTAL30® sphere is manufactured in Germany.

                                                                                                            PRECISION1® sphere is manufactured in the United States and also in Singapore.

                                                                                                            PRECISION1® toric is manufactured in Germany.

                                                                                                            DAILIES® AQUACOMFORT® PLUS sphere is manufactured in the United States and also in Singapore.

                                                                                                            DAILIES® AQUACOMFORT® PLUS multifocal is manufactured in the United States.

                                                                                                            DAILIES® AQUACOMFORT® PLUS toric is manufactured in the United States and also in Germany.

                                                                                                            AIR OPTIX® (all designs) are manufactured in the Malaysia and Indonesia.

                                                                                                            Alcon contact lenses do not contain dry natural rubber or natural rubber latex.

                                                                                                            Opti-Free PureMoist

                                                                                                              The raw materials used to manufacture OPTI-FREE* PUREMOIST* do not contain/contact animal tissues or derivatives.

                                                                                                              The OPTI-FREE® lens case is made of #5 polypropylene. Alcon recommends checking with your municipal recycling center for which materials are accepted for recycling in your region/area.

                                                                                                              OPTI-FREE® PUREMOIST® Multi-Purpose Disinfecting Solution is approved for use with all soft contact lenses. OPTI-FREE PUREMOIST is not approved for use with gas permeable lenses.

                                                                                                              OPTI-FREE® PUREMOIST® is not approved for short-term storage of lenses. Lenses should be stored in the closed lens case overnight or at least 6 hours.

                                                                                                              OPTI-FREE™ PureMoist™ Solution is not indicated for use directly in the eye.
                                                                                                              OPTI-FREE™ PureMoist™ Solution is indicated for use in the daily cleaning, reconditioning, rinsing, removing protein deposits, reducing lipid deposition, chemical (not heat) disinfection, and storage of silicone hydrogel and soft (hydrophilic) contact lenses as recommended by the eye care professional.
                                                                                                              Per the OPTI-FREE™ PureMoist™ Solution Instructions for Use, “Store lenses in the closed lens case overnight or at least 6 hours. After soaking, lenses are ready to wear. If any debris remains on contact lenses, rinse with OPTI-FREE™ PureMoist™ Solution prior to lens insertion.”

                                                                                                              OptiFree Replenish

                                                                                                                OPTI-FREE® REPLENISH® Multi-Purpose Disinfecting Solution is made in the USA with global materials. For proprietary reasons, Alcon does not publish information regarding ingredient sourcing. Alcon obtains source ingredients and materials from a worldwide network of global suppliers.

                                                                                                                OPTI-FREE® REPLENISH® does not contain benzalkonium chloride (BAK).

                                                                                                                Precision1

                                                                                                                  [NOTE to Medical Information team: The response below can be provided in writing or verbally]

                                                                                                                   

                                                                                                                  PFAS are not used in the formulation of or intentionally added to PRECISION1® contact lenses.
                                                                                                                  Alcon contact lenses have been shown to be safe and are used daily by millions of people in more than 140 countries. All of Alcon’s contact lenses meet our stringent internal safety standards and comply with the regulatory requirements of the U.S. Food and Drug Administration, European Chemicals Agency, or similar regulatory bodies in all of the markets in which we sell our products.

                                                                                                                  Total30

                                                                                                                    Alcon contact lens materials are not manufactured from ingredients derived from animals, and do not contain the ‘alpha-gal’ (galactose-alpha-1,3-galactose) molecule. Despite the lack of alpha-gal, Alcon is unable to state specifically that a contact lens product would not cause a reaction for a given patient. Alcon recommends working with the patient’s allergist for guidance.

                                                                                                                    Total30 for Astigmatism

                                                                                                                      Neither TOTAL30™ soft contact lenses nor the package storage saline is manufactured with boric acid.

                                                                                                                      TOTAL30™ for Astigmatism (lehfilcon A) toric contact lenses feature a scribe line on the front lens surface to enable assessment of the lens orientation. This line is at 6 o’clock approximately 1.0 mm in from the lens edge.

                                                                                                                       

                                                                                                                      In addition, TOTAL30® for Astigmatism has a small “C” engraving at 12 o’clock.

                                                                                                                      Services

                                                                                                                       

                                                                                                                      Product Family 1

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