Key Messages

Artificial tears are designed to lubricate the ocular surface by mimicking the natural tears through the use of various viscosity-enhancing agents, including but not limited to hydroxypropyl-guar (HPguar) and sodium hyaluronate (HA).

SYSTANE^® HYDRATION PF is a new unit-dose, preservative-free artificial tear containing dual demulcents (propylene glycol and polyethylene glycol 400) and a unique combination of both HPguar and HA polymers to leverage the water-retentive and viscoelastic properties of the HA, and the mucoadhesive properties of the HP-guar, to enhance ocular surface residence time and spread of demulcents in the formulation.

he dual-demulcent, dual-polymer artificial tear (SYSTANE^® HYDRATION PF) provides statistically significantly improved protection against desiccation through increased surface retention time compared to single-polymer (HP-guar or HA) formulations, and it also reduces surface friction and maintains lubricity to a greater extent than the HA single-polymer formulation.